上海科技大学两项成果登上《科学》 - 2020年04月29日

A team from the Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, has become the first in the world to discover the precise molecular mechanism which makes anti-tuberculosis (TB) drugs effective. The breakthrough will provide a fundamental structural basis for the development of new anti-TB drugs targeting resistance.
Their findings have been published in the international journal Science.
TB, caused by the bacteria Mycobacterium tuberculosis, is one to the most common fatal diseases worldwide. Popular anti-TB drugs in current clinical therapeutics have been developed over more than half a century. Of great concern, however, is the emergence of multi-drug-resistant and extensively drug-resistant TB strains. Consequently there is an urgent need to understand the drug targets and to develop new anti-TB drugs.