研究发现体外合成环形RNA的免疫原性机制及其潜在应用 - 2021年12月29日

Scientists in Shanghai have decoded the mysterious cellular mechanism that synthesizes double-stranded RNA in plants, marking a major breakthrough on the frontier of studies in molecular biology.

The research, led by the Center of Excellence in Molecular Plant Sciences at the Chinese Academy of Science (CEMPS), determined the three-dimensional structures of a two-polymerase complex that produces double-stranded RNA.

It revealed how DNA–dependent RNA polymerases – Pol IV and RDR2 – are assembled into a tight two–RNA–polymerase complex and efficiently produce double-stranded RNA using genomic double-stranded DNA as the template.